T cells are white blood cells that initiate and regulate immune responses that are important for clearing infections and cancers. A key aim of our laboratory is to understand the 'calculation' that T cells make in deciding to respond to abnormal infected or cancerous cells whilst ignoring healthy cells. This calculation is performed by their complex signalling machinery that integrates signals from a host of surface receptors. We are using a combination of quantitative experiments and mathematical modelling to uncover the signal integration mechanisms employed by T cells with the aim of exploiting this knowledge for the benefit of human health
We are located in the Oxford Molecular Pathology Institute, which is part of the Sir William Dunn School of Pathology at the University of Oxford. We have extensive collaborations with the Wolfson Centre for Mathematical Biology.
Student Positions: We are currently recruiting for D.Phil students (details here).